Search results for "Cochlear duct"

showing 3 items of 3 documents

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

2016

In recent years, primary cilia have emerged as key regulators in development and disease by influencing numerous signaling pathways. One of the earliest signaling pathways shown to be associated with ciliary function was the non-canonical Wnt signaling pathway, also referred to as planar cell polarity (PCP) signaling. One of the best places in which to study the effects of planar cell polarity (PCP) signaling during vertebrate development is the mammalian cochlea. PCP signaling disruption in the mouse cochlea disrupts cochlear outgrowth, cellular patterning and hair cell orientation, all of which are affected by cilia dysfunction. The goal of this protocol is to describe the analysis of PCP…

0301 basic medicineCell signalingGeneral Chemical EngineeringStereocilia (inner ear)Cochlear ductBiologyGeneral Biochemistry Genetics and Molecular BiologyStereociliaMice03 medical and health sciencesHair Cells AuditorymedicineAnimalsCochleaGeneral Immunology and MicrobiologyGeneral NeuroscienceCiliumWnt signaling pathwayCell PolarityCochlear DuctEmbryo Mammalianmedicine.diseaseImmunohistochemistryCiliopathiesCochleaCell biologyDisease Models AnimalCiliopathyPhenotype030104 developmental biologymedicine.anatomical_structureMicroscopy Electron ScanningMedicinesense organsHair cellSignal TransductionJournal of Visualized Experiments
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On the Function of the Spiral Prominence

1967

The suppression of hematic circulation of the internal auditory artery of a guinea-pig causes the necrosis of all anatomic formations of the cochlear duct, with the exception of the organ of Corti of the vestibular segment. The author confirms his hypothesis about the origin of the cochlear endolymph and thinks that the prominence provides the vegetative life of the organ of Corti.

Vestibular systemEndolymphbusiness.industryGuinea PigseducationLabyrinthine FluidsCochlear ductGeneral MedicineAnatomyCochleaNecrosisLabyrinthine fluidsmedicine.anatomical_structureOtorhinolaryngologyInternal Auditory ArteryOrgan of Cortiotorhinolaryngologic diseasesmedicineAnimalssense organsbusinessCochleaSpiralActa Oto-Laryngologica
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Determination of Cochlear Duct Length With 3D Versus Two-dimensional Methods: A Retrospective Clinical Study of Imaging by Computed Tomography and Co…

2021

BACKGROUND The aim of this study was to compare three different methods for measurement of cochlear duct length (CDL) in the clinical setting for two different imaging modalities, namely computed tomography (CT) and cone-beam computed tomography (CBCT). PATIENTS AND METHODS One hundred temporal bone data sets (CT: n=50; CBCT: n=50) of non-malformed cochleae were retrospectively analyzed using three different CDL estimation techniques: 3D curved multiplanar reconstruction (cMPR), 2D cMPR and the A-value formula. RESULTS The data sets belonged to 60 patients (34 males, 26 females; mean age=50.28±18.58 years). For both imaging modalities, application of the 3D cMPR estimation technique led to …

PharmacologyCancer ResearchCone beam computed tomographymedicine.diagnostic_testbusiness.industryComputed tomographyMean ageCochlear ductMultiplanar reconstructionGeneral Biochemistry Genetics and Molecular BiologyCbct imagingRetrospective datamedicine.anatomical_structureTemporal bonemedicineNuclear medicinebusinessIn Vivo
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